1801959-12-5

1801959-12-5 structure
1801959-12-5 structure
  • Name: PE 22-28
  • Chemical Name: PE 22-28
  • CAS Number: 1801959-12-5
  • Molecular Formula: C35H55N11O9
  • Molecular Weight: 773.88
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
  • Create Date: 2022-12-02 21:28:42
  • Modify Date: 2024-01-12 11:45:26
  • PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1].

Name PE 22-28
Description PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1].
Related Catalog
Target

IC50: 0.12 nM (TREK-1)[1]

In Vitro PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM[1].
In Vivo PE 22-28 (i.p.; 3.0µg/kg) shows antidepressant property[1]. Animal Model: Naïve male C57Bl/6J mice[1] Dosage: 3.0µg/kg Administration: Intraperitoneal Result: Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.
Molecular Formula C35H55N11O9
Molecular Weight 773.88
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