(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid
Modify Date: 2024-02-04 19:39:14
![(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid Structure](https://www.chemsrc.com/caspic/363/1800017-49-5.png)
(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid structure
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Common Name | (1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid | ||
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| CAS Number | 1800017-49-5 | Molecular Weight | 437.55 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 690.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H27N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 371.6±34.3 °C | |
Use of (1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacidPI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1]. |
| Name | AZ044 |
|---|---|
| Synonym | More Synonyms |
| Description | PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1]. |
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| Related Catalog | |
| Target |
PI4KIIIα:9.0 (pIC50) PI4KIIIβ:6.6 (pIC50) PI3Kα:4.0 (pIC50) PI3Kβ:<3.7 (pIC50) PI3Kγ:5.0 (pIC50) PI3Kδ:<4.1 (pIC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 690.9±65.0 °C at 760 mmHg |
| Molecular Formula | C24H27N3O3S |
| Molecular Weight | 437.55 |
| Flash Point | 371.6±34.3 °C |
| Exact Mass | 437.177307 |
| LogP | 3.86 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.691 |
| Storage condition | store at -20℃ for one year（Powder） |
| 4-[({6-[1-(Cyclopropylmethyl)-2-oxo-1,2-dihydro-4-pyridinyl]-1,3-benzothiazol-2-yl}amino)methyl]cyclohexanecarboxylic acid |
| Cyclohexanecarboxylic acid, 4-[[[6-[1-(cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]- |