1800017-49-5

1800017-49-5 structure

Name: (1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid
Chemical Name: AZ044
CAS Number: 1800017-49-5
Molecular Formula: C₂₄H₂₇N₃O₃S
Molecular Weight: 437.55
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2019-06-16 18:49:54
Modify Date: 2024-02-04 19:39:14
PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1].

Name	AZ044
Synonyms	4-[({6-[1-(Cyclopropylmethyl)-2-oxo-1,2-dihydro-4-pyridinyl]-1,3-benzothiazol-2-yl}amino)methyl]cyclohexanecarboxylic acid Cyclohexanecarboxylic acid, 4-[[[6-[1-(cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-

Description	PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> PI4K
Target	PI4KIIIα:9.0 (pIC50) PI4KIIIβ:6.6 (pIC50) PI3Kα:4.0 (pIC50) PI3Kβ:<3.7 (pIC50) PI3Kγ:5.0 (pIC50) PI3Kδ:<4.1 (pIC50)
References	[1]. Raubo P, et al. Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93.