(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid

Names

[ Name ]:
(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid

[Synonym ]:
4-[({6-[1-(Cyclopropylmethyl)-2-oxo-1,2-dihydro-4-pyridinyl]-1,3-benzothiazol-2-yl}amino)methyl]cyclohexanecarboxylic acid
Cyclohexanecarboxylic acid, 4-[[[6-[1-(cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-

Biological Activity

[Description]:

PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Signaling Pathways >> PI3K/Akt/mTOR >> PI4K

[Target]

PI4KIIIα:9.0 (pIC50)

PI4KIIIβ:6.6 (pIC50)

PI3Kα:4.0 (pIC50)

PI3Kβ:<3.7 (pIC50)

PI3Kγ:5.0 (pIC50)

PI3Kδ:<4.1 (pIC50)

[References]

[1]. Raubo P, et al. Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
690.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₇N₃O₃S

[ Molecular Weight ]:
437.55

[ Flash Point ]:
371.6±34.3 °C

[ Exact Mass ]:
437.177307

[ LogP ]:
3.86

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.691

[ Storage condition ]:
store at -20℃ for one year（Powder）

Related Compounds

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