Heliquinomycin

Modify Date: 2025-08-20 17:48:24

Heliquinomycin structure	Common Name	Heliquinomycin
	CAS Number	178182-49-5	Molecular Weight	698.58100
	Density	1.72g/cm3	Boiling Point	966ºC at 760mmHg
	Molecular Formula	C₃₃H₃₀O₁₇	Melting Point	N/A
	MSDS	N/A	Flash Point	310.6ºC

Use of Heliquinomycin

Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].

Name	Heliquinomycin

Description	Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
Target	Topoisomerase I Topoisomerase II
In Vitro	Heliquinomycin (18 h) 对革兰氏阳性菌株表现出很强的抑制活性，MIC 值为 0.1-0.39 μM[1]。 Heliquinomycin 抑制 HeLa S3、LI210 白血病、IMC、癌、B16 黑色素瘤细胞的生长，IC50s 为 0-1.6 μg/mL[1]。 Heliquinomycin (30 和 100 μg/mL) 抑制拓扑异构酶 II 和 I 酶活性[2]。
In Vivo	Heliquinomycin (100 mg/kg, i.p.) 对小鼠没有任何毒性[1]。
References	[1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7. [2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6.

Density	1.72g/cm3
Boiling Point	966ºC at 760mmHg
Molecular Formula	C₃₃H₃₀O₁₇
Molecular Weight	698.58100
Flash Point	310.6ºC
Exact Mass	698.14800
PSA	247.18000
LogP	1.25890
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.72
InChIKey	MLFZQFHGXSVTGX-MCTZXALVSA-N
SMILES	COC(=O)c1cc2cc3c(c(O)c2c(=O)o1)OC1(Oc2c(O)c4c(c(O)c2C1OC1CC(OC)C(O)C(C)O1)C(=O)C=C(OC)C4=O)C(O)C3

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG9689000

CAS REGISTRY NUMBER :: 178182-49-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C33-H30-O17

MOLECULAR WEIGHT :: 698.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 49,752,1996

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Heliquinomycin

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.