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Heliquinomycin

Names

[ CAS No. ]:
178182-49-5

[ Name ]:
Heliquinomycin

Biological Activity

[Description]:

Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Topoisomerase I

Topoisomerase II


[In Vitro]

Heliquinomycin (18 h) 对革兰氏阳性菌株表现出很强的抑制活性，MIC 值为 0.1-0.39 μM[1]。 Heliquinomycin 抑制 HeLa S3、LI210 白血病、IMC、癌、B16 黑色素瘤细胞的生长，IC50s 为 0-1.6 μg/mL[1]。 Heliquinomycin (30 和 100 μg/mL) 抑制拓扑异构酶 II 和 I 酶活性[2]。

[In Vivo]

Heliquinomycin (100 mg/kg, i.p.) 对小鼠没有任何毒性[1]。

[References]

[1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7.  

[2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6.  

Chemical & Physical Properties

[ Density]:
1.72g/cm3

[ Boiling Point ]:
966ºC at 760mmHg

[ Molecular Formula ]:
C33H30O17

[ Molecular Weight ]:
698.58100

[ Flash Point ]:
310.6ºC

[ Exact Mass ]:
698.14800

[ PSA ]:
247.18000

[ LogP ]:
1.25890

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.72

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG9689000
CAS REGISTRY NUMBER :
178182-49-5
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C33-H30-O17
MOLECULAR WEIGHT :
698.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 49,752,1996

Related Compounds

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