Clorgyline hydrochloride

Modify Date: 2025-08-21 11:40:56

Clorgyline hydrochloride structure	Common Name	Clorgyline hydrochloride
	CAS Number	17780-75-5	Molecular Weight	308.631
	Density	N/A	Boiling Point	361.3ºC at 760mmHg
	Molecular Formula	C₁₃H₁₆Cl₃NO	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	172.3ºC
	Symbol	GHS06	Signal Word	Danger

Use of Clorgyline hydrochloride

Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.

Name	3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine,hydrochloride
Synonym	More Synonyms

Description	Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Metabolic Disease
References	[1]. Murphy DL, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). Journal of neural transmission. Supplementum 52: 39-48.

Boiling Point	361.3ºC at 760mmHg
Molecular Formula	C₁₃H₁₆Cl₃NO
Molecular Weight	308.631
Flash Point	172.3ºC
Exact Mass	307.029755
PSA	12.47000
LogP	4.12930
Vapour Pressure	2.1E-05mmHg at 25°C

Clorgyline hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UI0675000

CHEMICAL NAME :: Propylamine, 3-(2,4-dichlorophenoxy)-N-methyl-N-propargyl-, hydrochloride

CAS REGISTRY NUMBER :: 17780-75-5

LAST UPDATED :: 199509

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H15-Cl2-N-O.Cl-H

MOLECULAR WEIGHT :: 308.65

WISWESSER LINE NOTATION :: GR CG DO3N1&2UU1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,56,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H312-H332
Precautionary Statements	P280-P301 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22
RIDADR	UN 2811 6.1/PG 3
RTECS	UI0675000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2922299090

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs.

Int. J. Neuropsychopharmacol. 17(8) , 1269-82, (2014)

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual, religious and healing purposes that is being increas...

Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia-reperfusion injury in an in vivo rat model.

Leuk. Res. 88 , 302-6, (2011)

This study tested the hypothesis that the inhibition of semicarbazide-sensitive amine oxidase (SSAO) after ischemia could attenuate myocardial ischemia-reperfusion (I/R) injury.Anesthetized male Sprag...

The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries.

J. Auton. Pharmacol. 18 , 123-128, (1998)

1. Segments of human cystic, gastric and ileocolic arteries were obtained from patients undergoing surgery. 2. Segments of arterial tissues, the noradrenaline content of which ranged between 0.27 and ...

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride

2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-, hydrochloride (9CI)

CLORGYLINE HYDROCHLORIDE

Clorgyline HCl

N-[3-(2,4-Dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine hydrochloride (1:1)

B 9302

2-Propyn-1-amine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-, hydrochloride (1:1)

EINECS 241-760-5

N-[3-(2,4-Dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine hydrochloride (1:1)

clorgiline hydrochloride

N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride

Clorgiline (hydrochloride)

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