BGC 20-761

Modify Date: 2024-01-09 08:58:40

BGC 20-761 structure	Common Name	BGC 20-761
	CAS Number	17375-63-2	Molecular Weight	294.39100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BGC 20-761

BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1].

Name	2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine
Synonym	More Synonyms

Description	BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Human 5-HT6 Receptor:20 nM (Ki) Human 5-HT2A Receptor:69 nM (Ki) Human D2 Receptor:140 nM (Ki)
In Vitro	BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat Ki values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM)[1].
In Vivo	BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.)[1]. Animal Model: Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats[1] Dosage: 2.5 mg/kg, 5 mg/kg and 10 mg/kg Administration: Administered (i.p.) immediately after the training session for the social recognition test Result: Administered alone did not show any difference in social recognition as compared to saline treated control animals. However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition.
References	[1]. Ellen S Mitchell, et al. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology. 2006 Mar;50(4):412-20.

Molecular Formula	C₁₉H₂₂N₂O
Molecular Weight	294.39100
Exact Mass	294.17300
PSA	28.26000
LogP	3.94760

3-(2-Dimethylamino-aethyl)-indol-5-ol,Hydrogenoxalat

3-(2-dimethylamino-ethyl)-indol-5-ol,hydrogenoxalate

Bufotenin Oxalate

bufotenin monooxalate

[2-(5-methoxy-2-phenyl-indol-3-yl)-ethyl]-dimethyl-amine

3-(2-(Dimethylamino)ethyl)indol-5-ol oxalate

Indol-5-ol,oxalate

N,N-dimethyl-2-(5-hydroxy-1H-indol-3-yl)ethylamine oxalate

Bufotenin-bioxalat

N,N-dimethyl-2-(5-methoxy-2-phenylindol-3-yl)ethylamine

bufotenine monooxalate

DC Chemicals Limited
China
Product Name: BGC-20-761
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

BGC 20-761 suppliers

BGC 20-761 price

BGC 20-761

Use of BGC 20-761

Names

BGC 20-761 Biological Activity

Chemical & Physical Properties

Synonyms