BGC 20-1531 hydrochloride
Modify Date: 2023-01-11 17:21:51
BGC 20-1531 hydrochloride structure
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Common Name | BGC 20-1531 hydrochloride | ||
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| CAS Number | 1962928-26-2 | Molecular Weight | 529.005 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H25ClN2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BGC 20-1531 hydrochlorideBGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8); shows no appreciable affinity at a wide range of other receptors (including other prostanoid receptors), channels, transporters and enzymes (pKi < 5); competitively antagonizes PGE(2)-induced vasodilatation of human middle cerebral (pK(B) 7.8) and meningeal (pK(B) 7.6) arteries in vitro, and PGE(2)-induced increase in canine carotid blood flow in vivo. Migraine Phase 2 Discontinued |
| Name | 4-{[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl}-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furamide hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8); shows no appreciable affinity at a wide range of other receptors (including other prostanoid receptors), channels, transporters and enzymes (pKi < 5); competitively antagonizes PGE(2)-induced vasodilatation of human middle cerebral (pK(B) 7.8) and meningeal (pK(B) 7.6) arteries in vitro, and PGE(2)-induced increase in canine carotid blood flow in vivo. Migraine Phase 2 Discontinued |
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| References | References 1. Maubach KA, et al. Br J Pharmacol. 2009 Jan;156(2):316-27. 2. Antonova M, et al. J Headache Pain. 2011 Oct;12(5):551-9. View Related Products by Target Prostaglandin Receptor Migraine |
| Molecular Formula | C26H25ClN2O6S |
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| Molecular Weight | 529.005 |
| Exact Mass | 528.112183 |
| 2-Furancarboxamide, 4-[[4-(5-methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-, hydrochloride (1:1) |
| 4-{[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl}-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furamide hydrochloride (1:1) |