WYE 687 dihydrochloride

Modify Date: 2024-01-12 18:43:19

WYE 687 dihydrochloride structure	Common Name	WYE 687 dihydrochloride
	CAS Number	1702364-87-1	Molecular Weight	601.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₃₄Cl₂N₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WYE 687 dihydrochloride

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].

Name	WYE-687 dihydrochloride

Description	WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	mTOR:7 nM (IC50) mTORC1 mTORC2 PI3K alpha:81 nM (IC50) PI3K gamma:3.11 μM (IC50) CK1 gamma1:17.8 μM (IC50) p38 alpha:28.9 μM (IC50)
References	[1]. Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40. [2]. Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.

Molecular Formula	C₂₈H₃₄Cl₂N₈O₃
Molecular Weight	601.53

Hazard Codes	Xi

WYE 687 dihydrochloride

Use of WYE 687 dihydrochloride

Names

WYE 687 dihydrochloride Biological Activity

Chemical & Physical Properties

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