WYE 687 dihydrochloride

Names

[ CAS No. ]:
1702364-87-1

[ Name ]:
WYE 687 dihydrochloride

Biological Activity

[Description]:

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

mTOR:7 nM (IC50)

mTORC1

mTORC2

PI3K alpha:81 nM (IC50)

PI3K gamma:3.11 μM (IC50)

CK1 gamma1:17.8 μM (IC50)

p38 alpha:28.9 μM (IC50)


[References]

[1]. Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40.

[2]. Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H34Cl2N8O3

[ Molecular Weight ]:
601.53

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds