Adrenocorticotropic Hormone Fragment 1-24 human
Modify Date: 2025-08-22 16:46:53
Adrenocorticotropic Hormone Fragment 1-24 human structure
|
Common Name | Adrenocorticotropic Hormone Fragment 1-24 human | ||
|---|---|---|---|---|
| CAS Number | 16960-16-0 | Molecular Weight | 2933.437 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C136H210N40O31S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Adrenocorticotropic Hormone Fragment 1-24 humanTetracosactide (INN) is an analogue of adrenocorticotrophic hormone (ACTH), with the biological activity of stimulating production of corticosteroids in the adrenal cortex. Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro. |
| Name | Cosyntropin |
|---|---|
| Synonym | More Synonyms |
| Description | Tetracosactide (INN) is an analogue of adrenocorticotrophic hormone (ACTH), with the biological activity of stimulating production of corticosteroids in the adrenal cortex. Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro. |
|---|---|
| Related Catalog |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C136H210N40O31S |
| Molecular Weight | 2933.437 |
| Exact Mass | 2931.580566 |
| PSA | 1184.02000 |
| LogP | -3.27 |
| Index of Refraction | 1.681 |
| InChIKey | ZOEFCCMDUURGSE-SQKVDDBVSA-N |
| SMILES | CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)O)C(C)C)C(C)C)C(C)C |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| RIDADR | NONH for all modes of transport |
|---|---|
| WGK Germany | 3 |
| RTECS | GM7915000 |
|
An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.
J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015) Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M... |
|
|
The relationship between vitamin D status and adrenal insufficiency in critically ill children.
J. Clin. Endocrinol. Metab. 98(5) , E877-81, (2013) Recent studies in critically ill populations have suggested both adrenal insufficiency (AI) and vitamin D deficiency to be associated with worse clinical outcome. There are multiple mechanisms through... |
|
|
Free and total plasma cortisol measured by immunoassay and mass spectrometry following ACTH₁₋₂₄ stimulation in the assessment of pituitary patients.
J. Clin. Endocrinol. Metab. 98(5) , 1883-90, (2013) Measurement of plasma cortisol by immunoassay after ACTH₁₋₂₄ stimulation is used to assess the hypothalamic-pituitary-adrenal (HPA) axis. Liquid chromatography-tandem mass spectrometry (LCMS) has grea... |
| Cortrosyn |
| y-29-(4-hydroxybenzyl)-26-(hydroxymethyl)-17-(1H-imidazol-4-ylmethyl)-8-(1H-indol-3-ylmethyl)-23-[2-(methylsulfanyl)ethyl]-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatritria |
| L-proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl- |
| MFCD00167476 |
| L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-v alyl-L-lysyl-L-valyl-L-tyrosyl- |
| cosyntropin |
| α1-24-Corticotropin |
| L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline |
| EINECS 241-031-1 |
| Adrenocorticotropic Hormone Fragment 1-24 human, rat |
| Tetracosactide |
| L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy |
| L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy l-L-valyl-L-tyrosyl-L-proline |
| Porcine ACTH (1-24) |
| Tetracosactide Acetate |