GL Biochem (Shanghai) Ltd.
China
Product Name: SYSMEHFRWGKPVGKKR
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: ACTH (1-17)
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

7266-47-9

7266-47-9 structure

7266-47-9 structure

Name: ACTH [1-17]
Chemical Name: Adrenocorticotropic Hormone Fragment 1-17 human, rat
CAS Number: 7266-47-9
Molecular Formula: C₉₅H₁₄₅N₂₉O₂₃S
Molecular Weight: 2093.41000
Catalog: Peptides
Create Date: 2018-12-29 22:25:40
Modify Date: 2024-01-05 17:46:35
ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.

Name	Adrenocorticotropic Hormone Fragment 1-17 human, rat
Synonyms	ACTH (1-17) alpha1-17-Corticotropin alpha1-17-ACTH SYSMEHFRWGKPVGKKR

Description	ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor Research Areas >> Cancer Research Areas >> Neurological Disease Peptides
Target	Ki: 0.21 nM (human MC1 receptor)[1]
In Vitro	ACTH (1-17) is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a Ki value of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH[1]. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures[2].
In Vivo	Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier[3].
Cell Assay	Rat pituitary cells are incubated in the presence of varying concentrations of ACTH (1-17) (0.1 nM-1 μM). A significant increase of growth hormone secretion is documented with each concentration[1].
Animal Admin	Mice[3] The effects of ACTH (1-17) on the rate of DNA labeling in the metaphyseal bone of CD2F1 mice are tested on a chronopharmacological dosing schedule. Groups of mice that has been conditioned to a 12-hr light/12-hr dark schedule are injected at one of six different timepoints, 4 hr apart during ,a single 24-hr span with either a low (0.021 I.U/kg) or a high (20 I.U./kg) dose of ACTH (1-17). Control groups receive injections of a placebo at corresponding timepoints. Subgroups of mice are injected with [3H]thymidine ([3H]Tdr) to follow the changes in DNA labeling in the proximal tibial metaphysis at 15 min and 2, 4, 8, 12 and 24 hr after ACTH (1-17) or placebo treatment[3].
References	[1]. Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34. [2]. Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. [3]. Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6.

Molecular Formula	C₉₅H₁₄₅N₂₉O₂₃S
Molecular Weight	2093.41000
Exact Mass	2092.08000
PSA	889.75000
LogP	3.96140
Index of Refraction	1.685
Storage condition	-20°C

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