Vofopitant dihydrochloride
Modify Date: 2025-09-30 19:01:18
Vofopitant dihydrochloride structure
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Common Name | Vofopitant dihydrochloride | ||
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| CAS Number | 168266-51-1 | Molecular Weight | 505.36400 | |
| Density | N/A | Boiling Point | 542.5ºC at 760mmHg | |
| Molecular Formula | C21H25Cl2F3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 281.9ºC | |
Use of Vofopitant dihydrochlorideVofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1]. |
| Name | (2S,3S)-N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine,dihydrochloride |
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| Synonym | More Synonyms |
| Description | Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1]. |
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| Related Catalog | |
| Target |
pKi: 9.5 (NK1, rat), 10.6 (NK1, human)[1] |
| References |
| Boiling Point | 542.5ºC at 760mmHg |
|---|---|
| Molecular Formula | C21H25Cl2F3N6O |
| Molecular Weight | 505.36400 |
| Flash Point | 281.9ºC |
| Exact Mass | 504.14200 |
| PSA | 82.09000 |
| LogP | 5.59630 |
| Vapour Pressure | 7.83E-12mmHg at 25°C |
| InChIKey | YVNRXILPJNISEM-FFUVTKDNSA-N |
| SMILES | COc1ccc(-n2nnnc2C(F)(F)F)cc1CNC1CCCNC1c1ccccc1.Cl.Cl |
| Vofopitant dihydrochloride (USAN) |
| Vofopitant hydrochloride |
| Vofopitant HCl |