Venadaparib hydrochloride

Modify Date: 2024-01-07 11:31:22

Venadaparib hydrochloride structure	Common Name	Venadaparib hydrochloride
	CAS Number	1681020-60-9	Molecular Weight	442.91
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₄ClFN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Venadaparib hydrochloride

Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2].

Name	Venadaparib hydrochloride

Description	Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP1:1.4 nM (IC50) PARP2:1 nM (IC50)
In Vitro	Venadaparib (example 143; 6-10 days) shows potent growth inhibition of MDA-MB-436 cells and Capan-1 pancreatic cancer cells with IC50 values of ≤5nM and 50nM [2].
In Vivo	In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1].
References	[1]. Yong Man Kim, et al. First-in-human dose-finding study of venadaparib (IDX-1197), a potent and selective PARP inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology. 39, no. 15_suppl (May 20, 2021) 3107-3107. [2]. Jae-Hoon Kang, et al. A novel phtalazinone derivatives and manufacturing process thereof. WO2015037939A1.

Molecular Formula	C₂₃H₂₄ClFN₄O₂
Molecular Weight	442.91