Metaxalone

Modify Date: 2024-01-02 20:38:24

Metaxalone structure	Common Name	Metaxalone
	CAS Number	1665-48-1	Molecular Weight	221.252
	Density	1.1±0.1 g/cm3	Boiling Point	453.6±14.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₅NO₃	Melting Point	121-123ºC
	MSDS	Chinese USA	Flash Point	228.2±20.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Metaxalone

Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.

Name	Metaxalone
Synonym	More Synonyms

Description	Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. http://en.wikipedia.org/wiki/Metaxalone

Density	1.1±0.1 g/cm3
Boiling Point	453.6±14.0 °C at 760 mmHg
Melting Point	121-123ºC
Molecular Formula	C₁₂H₁₅NO₃
Molecular Weight	221.252
Flash Point	228.2±20.1 °C
Exact Mass	221.105194
PSA	47.56000
LogP	2.42
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.525
Storage condition	-20°C Freezer

Metaxalone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3850000

CHEMICAL NAME :: 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-

CAS REGISTRY NUMBER :: 1665-48-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H15-N-O3

MOLECULAR WEIGHT :: 221.28

WISWESSER LINE NOTATION :: T5MVOTJ D1OR C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 775 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 515 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1690 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,326,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 490 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	NONH for all modes of transport
RTECS	RQ3850000

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Precursor 8
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DownStream 0

Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.

Clin. Ther. 26(9) , 1355-67, (2004)

Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support.The aim of this review was to discuss the etiology of low back pain an...

Development of a Stability-Indicating RP-UPLC Method for Rapid Determination of Metaxalone and its Degradation Products in Solid Oral Dosage Form.

Sci. Pharm. 80(2) , 353-66, (2012)

A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination o...

Metaxalone (Skelaxin)-related death.

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The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatograp...

5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one

Metaxalone

5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one

5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone

2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-

Metaxolone

MFCD00867700

5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone

Skelaxin

EINECS 216-777-6

DC Chemicals Limited
China
Product Name: Metaxalone
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥385/10mg

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Metaxalone

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