Triglycidyl isocyanurate

Modify Date: 2024-01-01 21:56:06

Triglycidyl isocyanurate structure	Common Name	Triglycidyl isocyanurate
	CAS Number	2451-62-9	Molecular Weight	297.264
	Density	1.6±0.1 g/cm3	Boiling Point	501.1±15.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₅N₃O₆	Melting Point	95-98°C
	MSDS	Chinese USA	Flash Point	256.9±20.4 °C
	Symbol	GHS05, GHS06, GHS08	Signal Word	Danger

Use of Triglycidyl isocyanurate

Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].

Name	1,3,5-Triglycidyl isocyanurate
Synonym	More Synonyms

Description	Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Inflammation/Immunology
In Vitro	Triglycidyl isocyanurate (0-30 μM; 48 hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1]. Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Cell Viability Assay[1] Cell Line: A549, H460 and H1299 cells Concentration: 0 μM; 5 μM; 10 μM; 30 μM Incubation Time: 48 hours Result: Inhibited tumor cells growth in soft agar. Western Blot Analysis[1] Cell Line: A549, H460 and H1299 cells Concentration: 0 μM; 5 μM; 10 μM; 30 μM Incubation Time: 48 hours Result: Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres
In Vivo	Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice[2]. Animal Model: Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area[2] Dosage: 1.8 mg/kg and 3.6 mg/kg Administration: Subcutaneous injection; every 2–3 days for total seven times; 30 days Result: Inhibited the growth of xenograft tumors.
References	[1]. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143 [2]. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008

Density	1.6±0.1 g/cm3
Boiling Point	501.1±15.0 °C at 760 mmHg
Melting Point	95-98°C
Molecular Formula	C₁₂H₁₅N₃O₆
Molecular Weight	297.264
Flash Point	256.9±20.4 °C
Exact Mass	297.096100
PSA	103.59000
LogP	-2.77
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.635
Water Solubility	<0.1 g/100 mL at 20 ºC

Triglycidyl isocyanurate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ1994900

CHEMICAL NAME :: s-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)-

CAS REGISTRY NUMBER :: 2451-62-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H15-N3-O6

MOLECULAR WEIGHT :: 297.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1200 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990 *** REVIEWS *** ACGIH TLV-TWA 0.05 mg/m3 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997

Symbol	GHS05, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301 + H331-H317-H318-H340-H373-H412
Precautionary Statements	P201-P261-P273-P280-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R23/25;R41;R43;R48/22;R52/53
Safety Phrases	S53-S45-S61
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	XZ1994900
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933699090

Precursor 0
DownStream 2
CAS#:101-05-3 anilazine CAS#:1665-48-1 Metaxalone

HS Code	2933699090
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

Determination of triglycidyl isocyanurate from air samples by ultra-performance liquid chromatography coupled with coordination ion spray mass spectrometry.

Rapid Commun. Mass Spectrom. 29 , 913-8, (2015)

Ultra-performance liquid chromatography (UPLC) coupled with coordination ion spray tandem mass spectrometry was used for the analysis of air samples containing triglycidyl isocyanurate. The method is ...

Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans.

Cancer Res. 44(9) , 4151-6, (1984)

Teroxirone is an experimental triepoxide antitumor agent currently undergoing evaluation in clinical trials. We have developed an assay based on derivatization with diethyldithiocarbamate followed by ...

Occupational contact dermatitis from triglycidyl isocyanurate in a powder paint factory.

Contact Dermatitis 26(1) , 59, (1992)

XB 2615

tgt

(RS,RS,SR)-1,3,5-Tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione

Teroxirone

EINECS 219-514-3

TGIC

1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione,TGIC,Triglycidyl isocyanurate

1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)-

1,3,5-Tris(2-oxiranylmethyl)-1,3,5-triazinane-2,4,6-trione

Isocyanuric Acid Triglycidyl Ester

T6NVNVNVJ A1- BT3OTJ& C1- BT3OTJ& E1- BT3OTJ

1,3,5-triglycidyl-s-triazinetrione

MFCD00080670

araldite pt-810

triglycidyl

Triglycidyl Isocyanurate

TEPIC

Tris(2,3-epoxypropyl) Isocyanurate

TGIC,triglycidyl isocyanurate

1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione

glycidylisocyanurate

Isocyanuric Acid Tris(2,3-epoxypropyl) Ester

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Triglycidyl isocyanurate
Price: ￥308.0/100g ￥1128.0/500g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Triglycidyl isocyanurate
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3,5-Triglycidyl isocyanurate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 1,3,5-Triglycidyl isocyanurate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2451-62-9
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥550/10 mM * 1 mL in DMSO

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Triglycidyl isocyanurate

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