BMS-191095
Modify Date: 2024-01-11 12:09:56
BMS-191095 structure
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Common Name | BMS-191095 | ||
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| CAS Number | 166095-21-2 | Molecular Weight | 408.88100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H21ClN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-191095BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.Target: potassium channelin vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels. |
| Name | (3R,4S)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3-hydro xy-2,2-dimethyl-6-chromanecarbonitrile |
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| Synonym | More Synonyms |
| Description | BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.Target: potassium channelin vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels. |
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| Related Catalog | |
| References |
| Molecular Formula | C22H21ClN4O2 |
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| Molecular Weight | 408.88100 |
| Exact Mass | 408.13500 |
| PSA | 85.17000 |
| LogP | 4.21458 |
| Storage condition | 2-8℃ |
| BMS-191095 |