UP202-56

Modify Date: 2024-01-21 17:16:36

UP202-56 structure	Common Name	UP202-56
	CAS Number	163838-04-8	Molecular Weight	594.7
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₈N₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of UP202-56

UP202-56 is an adenosine analogue, which is an adenosinergic agonist.

Name	UP202-56

Description	UP202-56 is an adenosine analogue, which is an adenosinergic agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Inflammation/Immunology
Target	Adenosine Receptor[1][2]
In Vitro	The effects of oral administration of UP202-56, an adenosine analogue, are assessed on carrageenan-induced spinal c-Fos protein expression and peripheral oedema. Oral UP202-56 (10, 30 or 50 mg/kg) dose-dependently reduces the number of carrageenan-induced c-Fos like immunoreactivity (c-Fos-LI) neurons (r=0.931. P<0.0001), with the highest dose of UP202-56 producing 72±4% reduction of the total number of carrageenan-induced spinal c-Fos-LI neurons, and 12±3% and 33±6% of reduction of control carrageenan oedema at paw and ankle levels, respectively. UP202-56 dose-dependently reduces the spinal c-Fos protein expression in carrageenan model of inflammatory pain[1]. UP202-56 is an adenosinergic agonist[2].
References	[1]. Honoré P, et al. UP 202-56, an adenosine analogue, selectively acts via A1 receptors to significantly decrease noxiously-evoked spinal c-Fos protein expression. Pain. 1998 Apr;75(2-3):281-93. [2]. Camborde, Francois, et al. PHARMACEUTICAL COMBINATION WITH ANALGESIC ACTIVITY, CONTAINING AN ADENOSINERGIC AGONIST AND A COMPOUND SELECTED FROM OPIATES, BENZODIAZEPINES AND NMDA ANTAGONISTS. Patent Application WO/1999/029347.

Molecular Formula	C₃₄H₃₈N₆O₄
Molecular Weight	594.7
Storage condition	2-8℃