(Rac)-Nedisertib
Modify Date: 2025-08-21 12:52:53
(Rac)-Nedisertib structure
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Common Name | (Rac)-Nedisertib | ||
|---|---|---|---|---|
| CAS Number | 1637542-34-7 | Molecular Weight | 481.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H21ClFN5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Rac)-NedisertibRac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM[1]. |
| Name | Rac-Nedisertib |
|---|
| Description | Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
DNA-PK:<3 nM (IC50) |
| In Vitro | Rac-Nedisertib (Compound 137) potently inhibits DNA-PK, with an IC50 of <3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene) ).[1]. |
| References |
| Molecular Formula | C24H21ClFN5O3 |
|---|---|
| Molecular Weight | 481.91 |
| InChIKey | MOWXJLUYGFNTAL-UHFFFAOYSA-N |
| SMILES | COc1ccc(C(O)c2cc(-c3ncnc4cc(N5CCOCC5)ccc34)c(F)cc2Cl)nn1 |
| Storage condition | 2-8℃ |