1637542-34-7

1637542-34-7 structure

Name: (Rac)-Nedisertib
Chemical Name: Rac-Nedisertib
CAS Number: 1637542-34-7
Molecular Formula: C₂₄H₂₁ClFN₅O₃
Molecular Weight: 481.91
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA-PK
Create Date: 2019-06-02 20:27:18
Modify Date: 2024-01-22 13:20:30
Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM[1].

Name	Rac-Nedisertib

Description	Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
Target	DNA-PK:<3 nM (IC50)
In Vitro	Rac-Nedisertib (Compound 137) potently inhibits DNA-PK, with an IC50 of <3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene) ).[1].
References	[1]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.