PF-06462894
Modify Date: 2025-09-18 11:34:42
PF-06462894 structure
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Common Name | PF-06462894 | ||
|---|---|---|---|---|
| CAS Number | 1622291-66-0 | Molecular Weight | 329.393 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 487.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H23N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 248.4±31.5 °C | |
Use of PF-06462894A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM; possesses favorable properties and a predicted low clinical dose (2 mg twice daily), does not show any evidence of immune activation in a mouse drug allergy model. |
| Name | PF-06462894 |
|---|---|
| Synonym | More Synonyms |
| Description | A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM; possesses favorable properties and a predicted low clinical dose (2 mg twice daily), does not show any evidence of immune activation in a mouse drug allergy model. |
|---|---|
| References | References 1. Stepan AF, et al. J Med Chem. 2017 Sep 28;60(18):7764-7780. View Related Products by Target mGluR |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 487.1±55.0 °C at 760 mmHg |
| Molecular Formula | C18H23N3O3 |
| Molecular Weight | 329.393 |
| Flash Point | 248.4±31.5 °C |
| Exact Mass | 329.173950 |
| LogP | 1.35 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.593 |
| 6(R)-(2,2-Dimethyl-propyl)-2-(pyridin-2-ylmethoxy)-6,7-dihydro-9H-pyrimido[2,1-c][1,4]oxazin-4-one |
| Pyrimido[2,1-c][1,4]oxazin-4(9H)-one, 6-(2,2-dimethylpropyl)-6,7-dihydro-2-(2-pyridinylmethoxy)-, (6R)- |
| (6R)-6-(2,2-Dimethylpropyl)-2-(2-pyridinylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one |
| MFCD28137683 |
| PF-06462894 |