PF-06462894

Names

[ Name ]:
PF-06462894

[Synonym ]:
6(R)-(2,2-Dimethyl-propyl)-2-(pyridin-2-ylmethoxy)-6,7-dihydro-9H-pyrimido[2,1-c][1,4]oxazin-4-one
Pyrimido[2,1-c][1,4]oxazin-4(9H)-one, 6-(2,2-dimethylpropyl)-6,7-dihydro-2-(2-pyridinylmethoxy)-, (6R)-
(6R)-6-(2,2-Dimethylpropyl)-2-(2-pyridinylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one
MFCD28137683
PF-06462894

Biological Activity

[Description]:

A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM; possesses favorable properties and a predicted low clinical dose (2 mg twice daily), does not show any evidence of immune activation in a mouse drug allergy model.

[References]

References 1. Stepan AF, et al. J Med Chem. 2017 Sep 28;60(18):7764-7780. View Related Products by Target mGluR

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
487.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₃N₃O₃

[ Molecular Weight ]:
329.393

[ Flash Point ]:
248.4±31.5 °C

[ Exact Mass ]:
329.173950

[ LogP ]:
1.35

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds

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