Talampanel

Modify Date: 2025-08-20 18:27:47

Talampanel structure	Common Name	Talampanel
	CAS Number	161832-65-1	Molecular Weight	337.372
	Density	1.4±0.1 g/cm3	Boiling Point	528.9±60.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₁₉N₃O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	273.7±32.9 °C
	Symbol	GHS06, GHS09	Signal Word	Danger

Use of Talampanel

Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Target: AMPA [1]in vitro: Talampanel is a glutamate receptor inhibitor with anti-seizure activity.in vivo： Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2]

Name	1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
Synonym	More Synonyms

Description	Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Target: AMPA [1]in vitro: Talampanel is a glutamate receptor inhibitor with anti-seizure activity.in vivo： Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2]
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
References	[1]. Langan YM, et al. Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. Epilepsia. 2003 Jan;44(1):46-53. [2]. Paizs M, et al. Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. Amyotroph Lateral Scler. 2011 Sep;12(5):340-344.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

References

[1]. Langan YM, et al. Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. Epilepsia. 2003 Jan;44(1):46-53.

[2]. Paizs M, et al. Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. Amyotroph Lateral Scler. 2011 Sep;12(5):340-344.

Density	1.4±0.1 g/cm3
Boiling Point	528.9±60.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₉N₃O₃
Molecular Weight	337.372
Flash Point	273.7±32.9 °C
Exact Mass	337.142639
PSA	77.15000
LogP	1.23
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.675
Storage condition	2-8℃

Talampanel MSDS(Chinese)

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310-P501
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

Precursor 4
CAS#:196303-02-3 (7S)-7-methyl-5... CAS#:196303-03-4 (S)-acetic acid... CAS#:4676-39-5 Methyl piperony... CAS#:172542-26-6 (S)-[4-(3,4-Met...
DownStream 0

Kinampa

Talampanel

(R)-7-acetyl-5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

1-[(8R)-5-(4-Aminophenyl)-8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone

Ethanone, 1-[(8R)-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-7-yl]-

Ampanel

(R)-(-)-1-(4-aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine

(R)-7-Acetyl-5-(p-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Talampanel (INN)

(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzo-diazepine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Talampanel
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Talampanel (GYKI 53773)
Price: $550.0/100mg $1000.0/250mg $2100.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Talampanel (GYKI 53773)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: $106/10mM*1mLinDMSO

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Talampanel

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.