netoglitazone
netoglitazone structure
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Common Name | netoglitazone | ||
|---|---|---|---|---|
| CAS Number | 161600-01-7 | Molecular Weight | 381.420 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 599.5±30.0 °C at 760 mmHg | |
| Molecular Formula | C21H16FNO3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 316.4±24.6 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of netoglitazoneNetoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity[1]. |
| Name | 5-[[6-[(2-fluorophenyl)methoxy]naphthalen-2-yl]methyl]-1,3-thiazolidine-2,4-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Netoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity[1]. |
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| Related Catalog | |
| Target |
PPARα PPARγ |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 599.5±30.0 °C at 760 mmHg |
| Molecular Formula | C21H16FNO3S |
| Molecular Weight | 381.420 |
| Flash Point | 316.4±24.6 °C |
| Exact Mass | 381.083496 |
| PSA | 80.70000 |
| LogP | 4.50 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.668 |
| InChIKey | PKWDZWYVIHVNKS-UHFFFAOYSA-N |
| SMILES | O=C1NC(=O)C(Cc2ccc3cc(OCc4ccccc4F)ccc3c2)S1 |
| Storage condition | 2-8°C |
|
~65%
netoglitazone CAS#:161600-01-7 |
| Literature: Mitsubishi Chemical Corporation Patent: US5594016 A1, 1997 ; |
| Precursor 1 | |
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| DownStream 0 | |
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MCC-555-induced NAG-1 expression is mediated in part by KLF4.
Eur. J. Pharmacol. 637(1-3) , 30-7, (2010) Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a central role in cell differentiation, metabolism and tumorigenesis. We have investigated the therapeutic properties of 5-[[6-[(2-fl... |
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Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat.
Int. J. Exp. Pathol. 84(2) , 83-9, (2003) The Zucker Diabetic Fatty (ZDF) rat is a model of impaired insulin sensitivity arising from hyperphagia owing to a mutation in the leptin receptor. In time, young ZDF rats, which are not initially dia... |
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Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation.
Exp. Cell Res. 310(1) , 196-204, (2005) Histone deacetylase-inhibitors affect growth and differentiation of intestinal epithelial cells by inducing expression of several transcription factors, e.g. Peroxisome proliferator-activated receptor... |
| 5-({6-[(2-Fluorobenzyl)oxy]-2-naphthyl}methyl)-1,3-thiazolidine-2,4-dione |
| 2,4-Thiazolidinedione, 5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]- |
| UNII-QOV2JZ647A |
| Isaglitazone |
| 5-({6-[(2-fluorobenzyl)oxy]naphthalen-2-yl}methyl)-1,3-thiazolidine-2,4-dione |
| MCC-555 |
| netoglitazone |