ML318

Modify Date: 2025-08-27 00:44:05

ML318 Structure
ML318 structure
Common Name ML318
CAS Number 1610516-67-0 Molecular Weight 280.22
Density N/A Boiling Point N/A
Molecular Formula C14H8F4N2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of ML318


ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].

 Names

Name ML318

 ML318 Biological Activity

Description ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].
Related Catalog
Target

IC50: 20 nM (PvdQ acylase)[1]

References

[1]. Jacqueline M Wurst, et al. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chem Biol. 2014 Jul 18;9(7):1536-44.

 Chemical & Physical Properties

Molecular Formula C14H8F4N2
Molecular Weight 280.22

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310 + P330
Hazard Codes Xi
RIDADR UN 2811 6.1 / PGIII
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