1610516-67-0

1610516-67-0 structure

Name: ML318
Chemical Name: ML318
CAS Number: 1610516-67-0
Molecular Formula: C₁₄H₈F₄N₂
Molecular Weight: 280.22
Catalog: Research Areas Infection
Create Date: 2020-08-10 19:32:39
Modify Date: 2025-08-27 00:44:05
ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].

Name	ML318

Description	ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 20 nM (PvdQ acylase)[1]
References	[1]. Jacqueline M Wurst, et al. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chem Biol. 2014 Jul 18;9(7):1536-44.

Molecular Formula	C₁₄H₈F₄N₂
Molecular Weight	280.22