ML318

Names

[ Name ]:
ML318

Biological Activity

[Description]:

ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 20 nM (PvdQ acylase)[1]

[References]

[1]. Jacqueline M Wurst, et al. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chem Biol. 2014 Jul 18;9(7):1536-44.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₈F₄N₂

[ Molecular Weight ]:
280.22

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310 + P330

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds

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