DMP 543

Modify Date: 2024-01-20 11:38:54

DMP 543 structure	Common Name	DMP 543
	CAS Number	160588-45-4	Molecular Weight	412.43
	Density	1.319g/cm3	Boiling Point	593.1ºC at 760mmHg
	Molecular Formula	C₂₆H₁₈F₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	312.5ºC

Use of DMP 543

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

Name	10,10-bis[(2-fluoropyridin-4-yl)methyl]anthracen-9-one
Synonym	More Synonyms

Description	DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	KV7 channel
In Vitro	DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].
References	[1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Density	1.319g/cm3
Boiling Point	593.1ºC at 760mmHg
Molecular Formula	C₂₆H₁₈F₂N₂O
Molecular Weight	412.43
Flash Point	312.5ºC
Exact Mass	412.13900
PSA	42.85000
LogP	5.07070
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.643

HMS3268N10

TCN 237 dihydrochloride

DMP 543

DC Chemicals Limited
China
Product Name: DMP 543
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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