Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

Modify Date: 2024-01-02 11:53:26

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH Structure
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH structure
Common Name Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH
CAS Number 159439-02-8 Molecular Weight 803.705
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C32H46N5O17P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH


Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].

 Names

Name N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu,N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamicacid
Synonym More Synonyms

 Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH Biological Activity

Description Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].
Related Catalog
References

[1]. G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C32H46N5O17P
Molecular Weight 803.705
Exact Mass 803.262634
PSA 371.27000
LogP -2.73
Index of Refraction 1.573

 Synonyms

N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid
N-ACETYL-O-PHOSPHONO-TYR-GLU-GLU-ILE-GLU
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Glu-Ile-Glu
AC-YEEIE
AC-PYEEIE TRIFLUOROACETATE SALT
N-ACETYL-O-PHOSPHONE-TYR-GLU*DIPENTYLAMI
M.W. 803.71 C32H46N5O17P
L-Glutamic acid, N-acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-
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