103253-15-2

103253-15-2 structure

Name: L-655,240
Chemical Name: 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methylindol-2-yl]-2,2-dimethylpropanoic acid
CAS Number: 103253-15-2
Molecular Formula: C₂₁H₂₁ClFNO₂
Molecular Weight: 373.84800
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2017-11-01 09:04:39
Modify Date: 2024-04-02 10:04:05
L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders[1].

Name	3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methylindol-2-yl]-2,2-dimethylpropanoic acid
Synonyms	N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu L-655,240 Lopac-L-9539 Tocris-1698

Description	L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
In Vitro	L 655240 (7 nM) 抑制人血小板中内过氧化物诱导的聚集[1]。
In Vivo	L 655240 (0.3 mg/kg；静脉注射；单次剂量) 改变犬类模型的发热率、动脉和肺动脉血压以及心输出量[1]。
References	[1]. Wainwright CL, et al. The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol. 1988 Sep;12(3):264-71.