L-655,240

Modify Date: 2025-08-23 19:07:07

L-655,240 Structure
L-655,240 structure
 Common Name L-655,240
CAS Number 103253-15-2 Molecular Weight 373.84800
Density 1.22g/cm3 Boiling Point 548.7ºC at 760mmHg
Molecular Formula C21H21ClFNO2 Melting Point N/A
MSDS N/A Flash Point 285.7ºC

 Use of L-655,240


L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders[1].

 Names

Name 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methylindol-2-yl]-2,2-dimethylpropanoic acid
Synonym More Synonyms

 L-655,240 Biological Activity

Description L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders[1].
Related Catalog
In Vitro L 655240 (7 nM) 抑制人血小板中内过氧化物诱导的聚集[1]。
In Vivo L 655240 (0.3 mg/kg；静脉注射；单次剂量) 改变犬类模型的发热率、动脉和肺动脉血压以及心输出量[1]。
References

[1]. Wainwright CL, et al. The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol. 1988 Sep;12(3):264-71.  

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 548.7ºC at 760mmHg
Molecular Formula C21H21ClFNO2
Molecular Weight 373.84800
Flash Point 285.7ºC
Exact Mass 373.12400
PSA 42.23000
LogP 5.44380
Vapour Pressure 7.1E-13mmHg at 25°C
Index of Refraction 1.581

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S36/37/39

 Synonyms

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
L-655,240
Lopac-L-9539
Tocris-1698
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