159439-02-8

159439-02-8 structure

Name: Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH
Chemical Name: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu,N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamicacid
CAS Number: 159439-02-8
Molecular Formula: C₃₂H₄₆N₅O₁₇P
Molecular Weight: 803.705
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
Create Date: 2018-07-25 10:45:24
Modify Date: 2024-01-02 11:53:26
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].

Name	N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu,N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamicacid
Synonyms	N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid N-ACETYL-O-PHOSPHONO-TYR-GLU-GLU-ILE-GLU N-Acetyl-O-phosphono-Tyr-Glu-Glu-Glu-Ile-Glu AC-YEEIE AC-PYEEIE TRIFLUOROACETATE SALT N-ACETYL-O-PHOSPHONE-TYR-GLU*DIPENTYLAMI M.W. 803.71 C32H46N5O17P L-Glutamic acid, N-acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-

Description	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
References	[1]. G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.