Cariporide Mesylate

Modify Date: 2025-08-26 17:13:51

Cariporide Mesylate Structure
Cariporide Mesylate structure
Common Name Cariporide Mesylate
CAS Number 159138-81-5 Molecular Weight 379.45200
Density N/A Boiling Point 542.8ºC at 760mmHg
Molecular Formula C13H21N3O6S2 Melting Point N/A
MSDS N/A Flash Point 282.1ºC

 Use of Cariporide Mesylate


Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1[1].

 Names

Name N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide,methanesulfonic acid
Synonym More Synonyms

 Cariporide Mesylate Biological Activity

Description Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1[1].
Related Catalog
References

[1]. Wang SX, et al. Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of intercellular adhesion molecule-1. Life Sci. 2006 Aug 29;79(14):1399-404.  

 Chemical & Physical Properties

Boiling Point 542.8ºC at 760mmHg
Molecular Formula C13H21N3O6S2
Molecular Weight 379.45200
Flash Point 282.1ºC
Exact Mass 379.08700
PSA 187.73000
LogP 3.87720
Vapour Pressure 7.62E-12mmHg at 25°C

 Synthetic Route

~77%

Cariporide Mesylate Structure

Cariporide Mesylate

CAS#:159138-81-5

Literature: Weichert, Andreas; Faber, Sabine; Jansen, Hans W.; Scholz, Wolfgang; Lang, Hans J. Arzneimittel-Forschung/Drug Research, 1997 , vol. 47, # 11 p. 1204 - 1207

~%

Cariporide Mesylate Structure

Cariporide Mesylate

CAS#:159138-81-5

Literature: Weichert, Andreas; Faber, Sabine; Jansen, Hans W.; Scholz, Wolfgang; Lang, Hans J. Arzneimittel-Forschung/Drug Research, 1997 , vol. 47, # 11 p. 1204 - 1207

~%

Cariporide Mesylate Structure

Cariporide Mesylate

CAS#:159138-81-5

Literature: Weichert, Andreas; Faber, Sabine; Jansen, Hans W.; Scholz, Wolfgang; Lang, Hans J. Arzneimittel-Forschung/Drug Research, 1997 , vol. 47, # 11 p. 1204 - 1207

 Synonyms

4-isopropyl-3-methylsulfonylbenzoylguanidine methanesulfonate
Cariporide mesylate
Cariporide mesilate
Cariporide mesylate (USAN)
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