4-ethoxymethylene-2-phenyl-2-oxazolin-5-one

Modify Date: 2024-01-14 07:27:32

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure
4-ethoxymethylene-2-phenyl-2-oxazolin-5-one structure
 Common Name 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one
CAS Number 15646-46-5 Molecular Weight 217.22
Density 1.18 g/cm3 Boiling Point 308.8ºC at 760 mmHg
Molecular Formula C12H11NO3 Melting Point 94-96 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 136.8ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one


Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1].

 Names

Name 4-(ethoxymethylene)-2-phenyloxazol-5-one
Synonym More Synonyms

  Biological Activity

Description Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1].
Related Catalog
Target

IL-4

IL-13

TNFR1
References

[1]. Weigmann B, et al. Oxazolone-Induced Colitis as a Model of Th2 Immune Responses in the Intestinal Mucosa. Methods Mol Biol. 2016;1422:253-61.  

 Chemical & Physical Properties

Density 1.18 g/cm3
Boiling Point 308.8ºC at 760 mmHg
Melting Point 94-96 °C (dec.)(lit.)
Molecular Formula C12H11NO3
Molecular Weight 217.22
Flash Point 136.8ºC
Exact Mass 217.07400
PSA 47.89000
LogP 1.30350
Vapour Pressure 0.000666mmHg at 25°C
Index of Refraction 1.561
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RQ5786250
CHEMICAL NAME :
2-Oxazolin-5-one, 4-ethoxymethylene-2-phenyl-
CAS REGISTRY NUMBER :
15646-46-5
LAST UPDATED :
198209
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H11-N-O3
MOLECULAR WEIGHT :
217.24
WISWESSER LINE NOTATION :
T5NYVOJ BU1O2 ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06780

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R43
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS RQ5786250
HS Code 2934999090

 Synthetic Route

Hippuric acid structure

Hippuric acid

CAS#:495-69-2
Triethyl orthoformate structure

Triethyl orthof...

CAS#:122-51-0

~67%

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure

4-ethoxymethyle...

CAS#:15646-46-5
Literature: Tikdari, Ahmad Momeni; Hamidian, Hooshang; Razee, Saeid Phosphorus, Sulfur and Silicon and the Related Elements, 2002 , vol. 177, # 12 p. 2821 - 2826
3,3-diethoxy-2-benzoylamino-propionic acid structure

3,3-diethoxy-2-...

CAS#:719302-55-3

~%

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure

4-ethoxymethyle...

CAS#:15646-46-5
Literature: Chem. Penicillin, , S. 688, 808 Zhurnal Obshchei Khimii, , vol. 21, p. 562 Chem.Abstr., , # 8513
3-ethoxy-2-benzoylamino-acrylic acid structure

3-ethoxy-2-benz...

CAS#:120165-75-5

~%

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure

4-ethoxymethyle...

CAS#:15646-46-5
Literature: Zhurnal Obshchei Khimii, , vol. 22, p. 874,878; engl. Ausg. S. 935, 937
Hippuric acid structure

Hippuric acid

CAS#:495-69-2
Triethyl orthoformate structure

Triethyl orthof...

CAS#:122-51-0
2,4-Pentandione structure

2,4-Pentandione

CAS#:123-54-6

~42%

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure

4-ethoxymethyle...

CAS#:15646-46-5
Literature: Kepe, Vladimir; Kocevar, Marijan; Polanc, Solvenko; Vercek, Bojan; Tisler, Miha Tetrahedron, 1990 , vol. 46, # 6 p. 2081 - 2088
4-methoxymethylene-2-phenyl-4H-oxazol-5-one structure

4-methoxymethyl...

CAS#:345894-39-5

~%

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure

4-ethoxymethyle...

CAS#:15646-46-5
Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618
Hippuric acid structure

Hippuric acid

CAS#:495-69-2

~%

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure

4-ethoxymethyle...

CAS#:15646-46-5
Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618
Hippuric acid structure

Hippuric acid

CAS#:495-69-2
Ethyl formate structure

Ethyl formate

CAS#:109-94-4

~%

4-ethoxymethylene-2-phenyl-2-oxazolin-5-one Structure

4-ethoxymethyle...

CAS#:15646-46-5
Literature: Chemische Berichte, , vol. 96, p. 377 - 380

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

4-Ethoxymethylene-2-phenyloxazolin-5-one
EINECS 239-713-9
4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE
MFCD00003204
4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one
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Chemsrc provides CAS#:15646-46-5 MSDS, density, melting point, boiling point, structure, etc. Its name is 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one>> amp version: 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one

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