PSB 1115
PSB 1115 structure
|
Common Name | PSB 1115 | ||
|---|---|---|---|---|
| CAS Number | 152529-79-8 | Molecular Weight | 350.35000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H14N4O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PSB 1115PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1]. |
| Name | 4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid |
|---|---|
| Synonym | More Synonyms |
| Description | PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1]. |
|---|---|
| Related Catalog | |
| Target |
A2BR |
| In Vitro | PSB-1115 (100 μM) 在回肠/空肠段中抑制 TNBS (10 mM) 诱导的 ACh 收缩抑制现象[1]。 |
| In Vivo | PSB-1115 (0.5 mg/kg; i.p.; single dose, 20 min before the inhalation) antagonizes the inhibitory effect of non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice[2]. |
| References |
| Molecular Formula | C14H14N4O5S |
|---|---|
| Molecular Weight | 350.35000 |
| Exact Mass | 350.06800 |
| PSA | 146.29000 |
| LogP | 1.81740 |
| InChIKey | UYDRRQPGDSIMNU-UHFFFAOYSA-N |
| SMILES | CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2c1=O |
| Storage condition | -20°C |
|
~85%
PSB 1115 CAS#:152529-79-8 |
| Literature: Mueller, Christa E.; Shi, Dan; Manning, Malcolm; Daly, John W. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3341 - 3349 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Mueller, Christa E.; Shi, Dan; Manning, Malcolm; Daly, John W. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3341 - 3349 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Mueller, Christa E.; Shi, Dan; Manning, Malcolm; Daly, John W. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3341 - 3349 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Hayallah, Alaa M.; Sandoval-Ramirez, Jesus; Reith, Ulrike; Schobert, Ulrike; Preiss, Birgit; Schumacher, Britta; Daly, John W.; Mueller, Christa E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1500 - 1510 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043 |
|
~%
PSB 1115 CAS#:152529-79-8 |
| Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043 |
![Benzenesulfonic acid,4-[[(4-amino-1,2,3,6-tetrahydro-2,6-dioxo-1-propyl-5-pyrimidinyl)amino]carbonyl]- structure](https://image.chemsrc.com/caspic/402/152529-72-1.png)
![4-[[m-nitrophenoxy]sulfonyl]benzoic acid structure](https://image.chemsrc.com/caspic/159/666715-86-2.png)
![Benzenesulfonic acid,4-[[(4-amino-1,2,3,6-tetrahydro-2,6-dioxo-1-propyl-5-pyrimidinyl)amino]carbonyl]-,3-nitrophenyl ester structure](https://image.chemsrc.com/caspic/490/666715-95-3.png)
| Tocris-2009 |