H-Phe-Met-Arg-Phe-NH2 acetate salt

Modify Date: 2025-08-24 11:06:43

H-Phe-Met-Arg-Phe-NH2 acetate salt structure	Common Name	H-Phe-Met-Arg-Phe-NH2 acetate salt
	CAS Number	152165-14-5	Molecular Weight	658.81
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₄₆N₈O₆S	Melting Point	N/A
	MSDS	Chinese	Flash Point	N/A

Use of H-Phe-Met-Arg-Phe-NH2 acetate salt

Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons[1].

Name	fmrf amide
Synonym	More Synonyms

Description	Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	ED50: 23 nM (K+ current)[1]
In Vitro	In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acetate acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide acetate activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels[1]. Phe-Met-Arg-Phe, amide (1 μM) acetate significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas[2]. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) acetate is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM)[2].
In Vivo	Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 pM) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 pM) of FMRFamide is already developed after 5 min and lasted up to 30 min[3].
References	[1]. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. [2]. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. [3]. Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7.

Molecular Formula	C₃₁H₄₆N₈O₆S
Molecular Weight	658.81
Exact Mass	598.30500
PSA	243.61000
LogP	3.51940

h-phe-met-arg-phe-nh2 acoh

fmrf-nh2

phe-met-arg-phe-nh2

molluscan cardioexcitatory peptide

fmrfamide acetate salt

phe-met-arg-phe-nh2 1/2acoh 2h2o

h-phe-met-arg-phe-nh2

phe-met-arg-phe amide

fmrf-amide 1 1/2acoh 2h2o

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FMRF AMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

H-Phe-Met-Arg-Phe-NH2 acetate salt suppliers

H-Phe-Met-Arg-Phe-NH2 acetate salt price

H-Phe-Met-Arg-Phe-NH2 acetate salt

Use of H-Phe-Met-Arg-Phe-NH2 acetate salt

Names

H-Phe-Met-Arg-Phe-NH2 acetate salt Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.