Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phe-Met-Arg-Pheamide
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FMRF AMIDE
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Purity: 98.0%
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64190-70-1

64190-70-1 structure

64190-70-1 structure

Name: Phe-Met-Arg-Phe, amide
Chemical Name: fmrf amide
CAS Number: 64190-70-1
Molecular Formula: C₂₉H₄₂N₈O₄S
Molecular Weight: 598.76000
Catalog: Peptides
Create Date: 2016-01-15 09:14:25
Modify Date: 2025-08-25 17:53:28
Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.

Name	fmrf amide
Synonyms	phenylalanyl-methionyl-arginyl-phenylalaninamide Phe-Met-Arg-Phe-NH2 L-Phe-L-Met-L-Arg-L-Phe-NH2 L-PHE-MET phe-met Phe-Met-Arg-Phe-amide H-Phe-Met-Arg-Phe-NH2 L-Phe-L-Met L-PHENYLALANYL-L-METHIONINE Phe-Met-Arg-Phe, amide

Description	Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Peptides Research Areas >> Neurological Disease
Target	ED50: 23 nM (K+ current)[1]
In Vitro	In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels[1]. Phe-Met-Arg-Phe, amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM)[2].
In Vivo	Phe-Met-Arg-Phe, amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min[3].
References	[1]. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. [2]. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. [3]. Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7.

Density	1.32 g/cm3
Molecular Formula	C₂₉H₄₂N₈O₄S
Molecular Weight	598.76000
Exact Mass	598.30500
PSA	243.61000
LogP	3.51940
Index of Refraction	1.639

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Precursor 7
123197-28-4 13734-34-4 58810-06-3 123197-27-3
5241-58-7 85642-22-4 2488-15-5
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