Nitenpyram

Modify Date: 2024-01-02 10:10:07

Nitenpyram structure	Common Name	Nitenpyram
	CAS Number	150824-47-8	Molecular Weight	270.715
	Density	1.3±0.1 g/cm3	Boiling Point	417.2±45.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₅ClN₄O₂	Melting Point	72ºC
	MSDS	Chinese USA	Flash Point	206.1±28.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Nitenpyram

Nitenpyram is a calss of neonicotinoid and an insect nicotinic acetylcholine receptor (nAChR) agonist with an IC50 of 14 nM. Nitenpyram is an oral fast-acting insecticide used to suppress sucking insects on companion animals[1][2].

Name	(E)-nitenpyram
Synonym	More Synonyms

Description	Nitenpyram is a calss of neonicotinoid and an insect nicotinic acetylcholine receptor (nAChR) agonist with an IC50 of 14 nM. Nitenpyram is an oral fast-acting insecticide used to suppress sucking insects on companion animals[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR
In Vivo	Nitenpyram is administered orally (1 mg/kg) for the short-term control of fleas in dogs and cats. Fleas start to fall from the animals 30 minutes post-administration and one dose can protect animals for 1-2 days[1]. Since Nitenpyram is highly lipophilic, it is administered orally after the meal in order to induce bile flow to help dissolve the chemical, thereby increasing GI absorption of the drug. It is rapidly and completely absorbed from the GI tract in less than 90 minutes and is completely excreted in urine within 48 hours after oral administration to dogs and cats. Nitenpyram undergoes hydroxylation, followed by conjugation in the liver. The conjugates of Nitenpyram are excreted in the urine and Nitenpyram is not accumulated in body tissues. The plasma half-life of Nitenpyram in dogs and cats are 3 and 8 hours, respectively. It is likely that animals with liver and/or kidney problems may have longer plasma half-life of Nitenpyram[1].
References	[1]. Vo DT, et al. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22. [2]. Rust MK, et al. Efficacy and longevity of nitenpyram against adult cat fleas (Siphonaptera: Pulicidae). J Med Entomol. 2003 Sep;40(5):678-81.

Density	1.3±0.1 g/cm3
Boiling Point	417.2±45.0 °C at 760 mmHg
Melting Point	72ºC
Molecular Formula	C₁₁H₁₅ClN₄O₂
Molecular Weight	270.715
Flash Point	206.1±28.7 °C
Exact Mass	270.088348
PSA	73.98000
LogP	1.90
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.568
Storage condition	0-6°C

Nitenpyram MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
RTECS	KH8589450
HS Code	2933399027

HS Code	2933399027
Summary	2933399027 2-(tert-butyl)-5-((4-(tert-butyl)benzyl)thio)-4-chloropyridazin-3(2h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Capillary electrophoresis-mass spectrometry as a new approach to analyze neonicotinoid insecticides.

J. Chromatogr. A. 1359 , 317-24, (2014)

This paper represents the first report of a capillary electrophoresis (CE) method compatible with mass spectrometry (MS) detection for simultaneously analyzing seven neonicotinoid insecticides (acetam...

Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

Simultaneous determination of neonicotinoid insecticides in sunflower-treated seeds (hull and kernel) by LC-MS/MS.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 33 , 442-51, (2016)

A validated analytical method to determine seven neonicotinoids (dinotefuran, nitenpyram, thiamethoxam, clothianidin, imidacloprid, acetamiprid and thiacloprid) in sunflower seeds (hull and kernel) us...

MFCD01631161

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DC Chemicals Limited
China
Product Name: Nitenpyram
Price: $450.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Nitenpyram
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Nitenpyram
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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