Ro 46-2005

Modify Date: 2024-01-16 11:47:48

Ro 46-2005 structure	Common Name	Ro 46-2005
	CAS Number	150725-87-4	Molecular Weight	473.542
	Density	1.3±0.1 g/cm3	Boiling Point	617.5±65.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₇N₃O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	327.3±34.3 °C

Use of Ro 46-2005

Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.IC50 value: 220 nM (ETA) [2]Target: Endothelinin vitro: Ro 46-2005 proves to be equipotent (IC50 200-500 nM) for inhibition of [125I]ET-1 binding on the two known ET receptor subtypes (ETA and ETB). Ro 46-2005 also inhibits the functional consequences of ET-1 stimulation: the ET-l-induced release of arachidonic acid from rat mesangial cells was inhibited with an IC50 of 1.8 μM.[1]

Name	4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide
Synonym	More Synonyms

Description	Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.IC50 value: 220 nM (ETA) [2]Target: Endothelinin vitro: Ro 46-2005 proves to be equipotent (IC50 200-500 nM) for inhibition of [125I]ET-1 binding on the two known ET receptor subtypes (ETA and ETB). Ro 46-2005 also inhibits the functional consequences of ET-1 stimulation: the ET-l-induced release of arachidonic acid from rat mesangial cells was inhibited with an IC50 of 1.8 μM.[1]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Cardiovascular Disease
References	[1]. Breu V, et al. In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETBreceptors. FEBS Lett. 1993 Nov 15;334(2):210-214. [2]. Clozel M, et al. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature. 1993 Oct 21;365(6448):759-761. [3]. N.R. Sibson, et al. MRI Determination of the Mechanisms Underlying TNF-a-induced Changes in Cerebral Blood Volume, Tissue Water Diffusion and BBB Permeability. Proc. Intl. Soc. Mag. Reson. Med. 10 (2002)

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

Research Areas >> Cardiovascular Disease

References

[1]. Breu V, et al. In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETBreceptors. FEBS Lett. 1993 Nov 15;334(2):210-214.

[2]. Clozel M, et al. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature. 1993 Oct 21;365(6448):759-761.

[3]. N.R. Sibson, et al. MRI Determination of the Mechanisms Underlying TNF-a-induced Changes in Cerebral Blood Volume, Tissue Water Diffusion and BBB Permeability. Proc. Intl. Soc. Mag. Reson. Med. 10 (2002)

Density	1.3±0.1 g/cm3
Boiling Point	617.5±65.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₇N₃O₆S
Molecular Weight	473.542
Flash Point	327.3±34.3 °C
Exact Mass	473.162048
PSA	128.25000
LogP	2.22
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.593
Storage condition	2-8℃

4-tert-butyl-N-...

CAS#:150727-29-0

Ro 46-2005

CAS#:150725-87-4

Literature: Hoffmann-La Roche Inc. Patent: US5292740 A1, 1994 ; US 5292740 A

Precursor 1
CAS#:150727-29-0 4-tert-butyl-N-...
DownStream 0

Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

N-[6-(2-Hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-4-(2-methyl-2-propanyl)benzenesulfonamide

Ro 46-2005

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide

DC Chemicals Limited
China
Product Name: Ro 46-2005
Price: $550.0/100mg $1100.0/250mg $2100.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ro 46-2005
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $462/10mM*1mLinDMSO

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Ro 46-2005

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