N,N-bis(2-hydroxyethyl)glycine

Modify Date: 2025-08-25 06:31:35

N,N-bis(2-hydroxyethyl)glycine Structure
N,N-bis(2-hydroxyethyl)glycine structure
Common Name N,N-bis(2-hydroxyethyl)glycine
CAS Number 150-25-4 Molecular Weight 163.17
Density 1.3±0.1 g/cm3 Boiling Point 388.5±27.0 °C at 760 mmHg
Molecular Formula C6H13NO4 Melting Point 190 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 188.8±23.7 °C

 Use of N,N-bis(2-hydroxyethyl)glycine


Bicine is a useful buffer in the range of physiological interest. Bicine is a derivative of the simple amino acid glycine[1].

 Names

Name N,N-bis(2-hydroxyethyl)glycine
Synonym More Synonyms

 N,N-bis(2-hydroxyethyl)glycine Biological Activity

Description Bicine is a useful buffer in the range of physiological interest. Bicine is a derivative of the simple amino acid glycine[1].
Related Catalog
References

[1]. Taha M, et al. Mixed-ligand complex formation equilibria of cobalt (II), nickel (II), and copper (II) with N, N-bis (2-hydroxyethyl) glycine (bicine) and some amino acids[J]. Journal of Chemical & Engineering Data, 2005, 50(1): 157-163.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 388.5±27.0 °C at 760 mmHg
Melting Point 190 °C (dec.)(lit.)
Molecular Formula C6H13NO4
Molecular Weight 163.17
Flash Point 188.8±23.7 °C
Exact Mass 163.084457
PSA 81.00000
LogP -0.47
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.526
InChIKey FSVCELGFZIQNCK-UHFFFAOYSA-N
SMILES O=C(O)CN(CCO)CCO
Storage condition 2-8°C
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB9700000
CHEMICAL NAME :
Glycine, N,N-dihydroxyethyl-
CAS REGISTRY NUMBER :
150-25-4
BEILSTEIN REFERENCE NO. :
1769362
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H13-N-O4
MOLECULAR WEIGHT :
163.20
WISWESSER LINE NOTATION :
QV1N2Q2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1540 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.1- 1953- Volume(issue)/page/year: 10,391,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9723 No. of Facilities: 130 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1828 (estimated) No. of Female Employees: 1552 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MB9700000
HS Code 29225000

 Synthetic Route

 Customs

HS Code 29225000

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 Synonyms

Diethylolglycine
N,N-Bis(2-hydroxyethyl)glycine,BICINE,PEG Grid Screening
Di(hydroxyethyl)glycine
Glycine, N, N-dihydroxyethyl-
N,N-Dihydroxyethyl glycine
bicine buffer
Bis(2-Hydroxyethyl)glycine
Bicine
BICINE[N,N-Di(2-hydroxyethyl)glycine]
EINECS 205-755-1
Bicene
N,N-Bis(b-hydroxyethyl)glycine
N,N-Di(2-hydroxyethyl)glycine
Glycine, N,N-bis(2-hydroxyethyl)-
Diethanolglycine
2-[bis(2-hydroxyethyl)amino]acetic acid
2-HxG
2-(bis(2-hydroxyethyl)amino)acetic acid
N,N-Bis(β-hydroxyethyl)glycine
MFCD00004295
(Bis(2-hydroxyethyl)amino)acetic Acid
Glycine, N,N-bis (2-hydroxyethyl)-
N,N-dihydroxyethylglycine
N,N-Bis(2-hydroxyethyl)aminoacetic acid
N,N-Bis(hydroxyethyl)glycine
N,N-Bis(2-hydroxyethyl)glycine
N,N-Di(2-hydroxyethyl)glycine [Good's buffer component
N,N-Di(hydroxyethyl)aminoacetic Acid
Diethanol glycine
N,N-Bis(2-hydroxyethyl)glycine (Bicine)
Dihydroxyethylglycine
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