N,N-bis(2-hydroxyethyl)glycine

Names

[ CAS No. ]:
150-25-4

[ Name ]:
N,N-bis(2-hydroxyethyl)glycine

[Synonym ]:
Diethylolglycine
N,N-Bis(2-hydroxyethyl)glycine,BICINE,PEG Grid Screening
Di(hydroxyethyl)glycine
Glycine, N, N-dihydroxyethyl-
N,N-Dihydroxyethyl glycine
bicine buffer
Bis(2-Hydroxyethyl)glycine
Bicine
BICINE[N,N-Di(2-hydroxyethyl)glycine]
EINECS 205-755-1
Bicene
N,N-Bis(b-hydroxyethyl)glycine
N,N-Di(2-hydroxyethyl)glycine
Glycine, N,N-bis(2-hydroxyethyl)-
Diethanolglycine
2-[bis(2-hydroxyethyl)amino]acetic acid
2-HxG
2-(bis(2-hydroxyethyl)amino)acetic acid
N,N-Bis(β-hydroxyethyl)glycine
MFCD00004295
(Bis(2-hydroxyethyl)amino)acetic Acid
Glycine, N,N-bis (2-hydroxyethyl)-
N,N-dihydroxyethylglycine
N,N-Bis(2-hydroxyethyl)aminoacetic acid
N,N-Bis(hydroxyethyl)glycine
N,N-Bis(2-hydroxyethyl)glycine
N,N-Di(2-hydroxyethyl)glycine [Good's buffer component
N,N-Di(hydroxyethyl)aminoacetic Acid
Diethanol glycine
N,N-Bis(2-hydroxyethyl)glycine (Bicine)
Dihydroxyethylglycine

Biological Activity

[Description]:

Bicine is a useful buffer in the range of physiological interest. Bicine is a derivative of the simple amino acid glycine[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Taha M, et al. Mixed-ligand complex formation equilibria of cobalt (II), nickel (II), and copper (II) with N, N-bis (2-hydroxyethyl) glycine (bicine) and some amino acids[J]. Journal of Chemical & Engineering Data, 2005, 50(1): 157-163.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
388.5±27.0 °C at 760 mmHg

[ Melting Point ]:
190 °C (dec.)(lit.)

[ Molecular Formula ]:
C₆H₁₃NO₄

[ Molecular Weight ]:
163.17

[ Flash Point ]:
188.8±23.7 °C

[ Exact Mass ]:
163.084457

[ PSA ]:
81.00000

[ LogP ]:
-0.47

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.526

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9700000

CHEMICAL NAME :: Glycine, N,N-dihydroxyethyl-

CAS REGISTRY NUMBER :: 150-25-4

BEILSTEIN REFERENCE NO. :: 1769362

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H13-N-O4

MOLECULAR WEIGHT :: 163.20

WISWESSER LINE NOTATION :: QV1N2Q2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1540 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.1- 1953- Volume(issue)/page/year: 10,391,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9723 No. of Facilities: 130 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1828 (estimated) No. of Female Employees: 1552 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MB9700000

[ HS Code ]:
29225000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29225000

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