Dexrazoxane HCl (ICRF-187, ADR-529)

Modify Date: 2024-01-05 20:56:11

Dexrazoxane HCl (ICRF-187, ADR-529) structure	Common Name	Dexrazoxane HCl (ICRF-187, ADR-529)
	CAS Number	149003-01-0	Molecular Weight	304.73000
	Density	N/A	Boiling Point	531.5ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₇ClN₄O₄	Melting Point	193ºC
	MSDS	N/A	Flash Point	275.3ºC

Use of Dexrazoxane HCl (ICRF-187, ADR-529)

Dexrazoxane Hcl( ICRF-187 Hcl) is a cardioprotective agent. IC50 value:Target: cardioprotective agentAs a derivative of EDTA, dexrazoxane chelates iron, thus reduce the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. This agent is used to protect the heart against the cardiotoxic side effects of anthracyclines, such as doxorubicin. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs.

Name	dexrazoxane hydrochloride
Synonym	More Synonyms

Description	Dexrazoxane Hcl( ICRF-187 Hcl) is a cardioprotective agent. IC50 value:Target: cardioprotective agentAs a derivative of EDTA, dexrazoxane chelates iron, thus reduce the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. This agent is used to protect the heart against the cardiotoxic side effects of anthracyclines, such as doxorubicin. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
References	[1]. Hasinoff BB. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs. 2008 Feb;17(2):217-23. [2]. Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7. [3]. Lipshultz SE, Scully RE, Lipsitz SR et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol. 201

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cardiovascular Disease

References

[1]. Hasinoff BB. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs. 2008 Feb;17(2):217-23.

[2]. Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7.

[3]. Lipshultz SE, Scully RE, Lipsitz SR et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol. 201

Boiling Point	531.5ºC at 760 mmHg
Melting Point	193ºC
Molecular Formula	C₁₁H₁₇ClN₄O₄
Molecular Weight	304.73000
Flash Point	275.3ºC
Exact Mass	304.09400
PSA	98.82000
Vapour Pressure	2.22E-11mmHg at 25°C
Storage condition	-20°C

Hazard Codes	Xi

2,6-Piperazinedione, 4-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-, hydrochloride (1:1)

4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dionhydrochlorid

4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione chlorhydrate

(S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedionehydrochloride

Dexrazoxane hydrochloride

2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, hydrochloride (1:1)

4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione) hydrochloride (1:1)

2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, monohydrochloride

4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione hydrochloride (1:1)

Dexrazoxane HCl

UNII:5346058Q7S

Dexrazoxane (Hydrochloride)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dexrazoxane HCl (ICRF-187, ADR-529)
Price: ￥1078.0/50mg ￥3288.0/250mg ￥338.0/10mg
Purity: 99.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Dexrazoxane Hydrochloride
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $66/10mM*1mLinDMSO

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Dexrazoxane HCl (ICRF-187, ADR-529)

Use of Dexrazoxane HCl (ICRF-187, ADR-529)

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