Higenamine HCl

Modify Date: 2025-08-20 18:54:25

Higenamine HCl Structure
Higenamine HCl structure
 Common Name Higenamine HCl
CAS Number 11041-94-4 Molecular Weight 307.772
Density N/A Boiling Point 522.4ºC at 760 mmHg
Molecular Formula C16H18ClNO3 Melting Point N/A
MSDS N/A Flash Point 209.6ºC

 Use of Higenamine HCl


Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2].

 Names

Name 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
Synonym More Synonyms

 Higenamine HCl Biological Activity

Description Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2].
Related Catalog
Target

β2-AR[1]

References

[1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.

[2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

 Chemical & Physical Properties

Boiling Point 522.4ºC at 760 mmHg
Molecular Formula C16H18ClNO3
Molecular Weight 307.772
Flash Point 209.6ºC
Exact Mass 307.097534
PSA 72.72000
LogP 3.36370
Vapour Pressure 1.56E-11mmHg at 25°C
InChIKey SWWQQSDRUYSMAR-UHFFFAOYSA-N
SMILES Cl.Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX0484380
CHEMICAL NAME :
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-
CAS REGISTRY NUMBER :
11041-94-4
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H17-N-O3.Cl-H
MOLECULAR WEIGHT :
307.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982

 Safety Information

HS Code 2933499090

 Synthetic Route

N/A structure

N/A

CAS#:117765-29-4

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
4-Benzyloxyphenylacetonitrile structure

4-Benzyloxyphen...

CAS#:838-96-0

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
TRANS-3 4-BENZYLOXY-TRANS-B-NITROSTYREN& structure

TRANS-3 4-BENZY...

CAS#:1699-54-3

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
4-Benzyloxyphenylacetyl Chloride structure

4-Benzyloxyphen...

CAS#:39188-62-0

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
[4-(Benzyloxy)phenyl]acetic acid structure

[4-(Benzyloxy)p...

CAS#:6547-53-1

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
3,4-Dibenzyloxyphenethylamine hydrochloride structure

3,4-Dibenzyloxy...

CAS#:1699-56-5

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide structure

N-(3,4-dibenzyl...

CAS#:23428-48-0

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
6,7-bisbenzyloxy-1-(4-benzyloxybenzyl)-3,4-dihydroisoquinoline hydrochloride structure

6,7-bisbenzylox...

CAS#:23428-49-1

~%

Higenamine HCl Structure

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one
1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1)
6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
Higenamine HCl
UNII:PQ432PID6E
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)
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