Higenamine HCl

Modify Date: 2024-01-02 14:42:25

Higenamine HCl structure	Common Name	Higenamine HCl
	CAS Number	11041-94-4	Molecular Weight	307.772
	Density	N/A	Boiling Point	522.4ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₈ClNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	209.6ºC

Use of Higenamine HCl

Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2].

Name	1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
Synonym	More Synonyms

Description	Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Endocrinology
Target	β2-AR[1]
References	[1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23. [2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

Boiling Point	522.4ºC at 760 mmHg
Molecular Formula	C₁₆H₁₈ClNO₃
Molecular Weight	307.772
Flash Point	209.6ºC
Exact Mass	307.097534
PSA	72.72000
LogP	3.36370
Vapour Pressure	1.56E-11mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX0484380

CHEMICAL NAME :: 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 11041-94-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H17-N-O3.Cl-H

MOLECULAR WEIGHT :: 307.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982

HS Code	2933499090

N/A

CAS#:117765-29-4

Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

4-Benzyloxyphen...

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Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

TRANS-3 4-BENZY...

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Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

4-Benzyloxyphen...

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Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

[4-(Benzyloxy)p...

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Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

3,4-Dibenzyloxy...

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Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

N-(3,4-dibenzyl...

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Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

6,7-bisbenzylox...

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Higenamine HCl

CAS#:11041-94-4

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

Precursor 7
CAS#:838-96-0 4-Benzyloxyphen... CAS#:1699-54-3 TRANS-3 4-BENZY... CAS#:39188-62-0 4-Benzyloxyphen... CAS#:6547-53-1 [4-(Benzyloxy)p...
CAS#:1699-56-5 3,4-Dibenzyloxy... CAS#:23428-48-0 N-(3,4-dibenzyl... CAS#:23428-49-1 6,7-bisbenzylox...
DownStream 0

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one

1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1)

6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Higenamine HCl

UNII:PQ432PID6E

6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Higenamine HCl
Price: ￥788.0/20mg ￥178.0/1g ￥428.0/5g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Demethyl
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥500/100 mg

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Higenamine HCl

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