2-chloro-1-(4-phenylpiperazin-1-yl)ethanone

Modify Date: 2024-01-03 10:07:13

2-chloro-1-(4-phenylpiperazin-1-yl)ethanone Structure
2-chloro-1-(4-phenylpiperazin-1-yl)ethanone structure
Common Name 2-chloro-1-(4-phenylpiperazin-1-yl)ethanone
CAS Number 14761-39-8 Molecular Weight 238.71300
Density 1.221g/cm3 Boiling Point 404.7ºC at 760mmHg
Molecular Formula C12H15ClN2O Melting Point 71-73ºC
MSDS N/A Flash Point 198.5ºC

 Names

Name 2-chloro-1-(4-phenylpiperazin-1-yl)ethanone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.221g/cm3
Boiling Point 404.7ºC at 760mmHg
Melting Point 71-73ºC
Molecular Formula C12H15ClN2O
Molecular Weight 238.71300
Flash Point 198.5ºC
Exact Mass 238.08700
PSA 23.55000
LogP 1.57690
Vapour Pressure 9.29E-07mmHg at 25°C
Index of Refraction 1.569

 MSDS

Name: 2-Chloro-1-(4-phenylpiperazino)ethan-1-one tech Material Safety Data Sheet
Synonym:
CAS: 14761-39-8
Section 1 - Chemical Product MSDS Name:2-Chloro-1-(4-phenylpiperazino)ethan-1-one tech Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
14761-39-8 2-Chloro-1-(4-phenylpiperazino)ethan-1 unlisted
Hazard Symbols: C
Risk Phrases: 20/21/22 34

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed. Causes burns.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Harmful if absorbed through the skin. Causes skin burns.
Ingestion:
Harmful if swallowed. Causes gastrointestinal tract burns.
Inhalation:
Harmful if inhaled. Causes chemical burns to the respiratory tract.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 14761-39-8: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 77 - 79 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C12H15ClN2O
Molecular Weight: 238.72

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 14761-39-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Chloro-1-(4-phenylpiperazino)ethan-1-one - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, TOXIC, N.O.S.*
Hazard Class: 8 (6.1)
UN Number: 2923
Packing Group: III
IMO
Shipping Name: CORROSIVE SOLID, TOXIC, N.O.S.
Hazard Class: 8 (6.1)
UN Number: 2923
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE SOLID, TOXIC, N.O.S.
Hazard Class: 8
UN Number: 2923
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 14761-39-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 14761-39-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 14761-39-8 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes C:Corrosive
Risk Phrases R20/21/22;R34
Safety Phrases S26-S36/37/39-S45
HS Code 2933599090

 Synthetic Route

~99%

2-chloro-1-(4-phenylpiperazin-1-yl)ethanone Structure

2-chloro-1-(4-p...

CAS#:14761-39-8

Literature: NAM, Ghilsoo; Choi, Kyung Il; Kim, Hye Ran; Seo, Seon Hee; Kim, Yoon Jee; Shin, Hee Sup; Kim, Dong Jin; Pae, Ae Nim; Chung, Hye Jin; Choo, Hyunah; Rhim, Hyewhon; Cho, Yong Seo; Roh, Eun Joo; Keum, Gyo Chang; Choi, Kee Hyun; Shin, Kye Jung; Hahn, Hoh Gyu; Cheong, Chan Seong; Lee, Jae Kyun; Nam, Kee Dal; Kang, Yong Koo; Kim, Youngsoo; Park, Woong Seo; Kim, Eunice Eun-Kyeong; Kim, Key-Sun; Chung, Hesson; Shin, Dong Yun; Song, Chi man Patent: US2010/94006 A1, 2010 ; Location in patent: Page/Page column 10 ;

~91%

2-chloro-1-(4-phenylpiperazin-1-yl)ethanone Structure

2-chloro-1-(4-p...

CAS#:14761-39-8

Literature: Zhang, Xiaoru; Yang, Xiaohui; Zhang, Shusheng Synthetic Communications, 2009 , vol. 39, # 5 p. 830 - 844

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-phenyl-1-chloroacetyl piperazine
1-phenyl-4-chloroacetyl-piperazine