Synthetic Communications®

Synthesis of triazole-linked glycoconjugates by copper (I)-catalyzed regiospecific cycloaddition of alkynes and azides

X Zhang, X Yang, S Zhang

Index: Zhang, Xiaoru; Yang, Xiaohui; Zhang, Shusheng Synthetic Communications, 2009 , vol. 39, # 5 p. 830 - 844

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Citation Number: 12

Abstract

Abstract Several 1, 2, 3-triazole-linked glycoconjugates were efficiently synthesized via a Cu (I)-mediated 1, 3-dipolar cycloaddition with high regiospecificity and yield (≥ 85%), providing a simple and efficient route to synthesize protected and unprotected neoglycoconjugates. Introduction of a spacer between glycosyl moieties and other compounds reduces steric hindrance, promotes yield, and expands the varieties of ...