NOC-5

Modify Date: 2024-01-05 18:23:16

NOC-5 Structure
NOC-5 structure
Common Name NOC-5
CAS Number 146724-82-5 Molecular Weight 176.217
Density 1.2±0.1 g/cm3 Boiling Point 270.1±42.0 °C at 760 mmHg
Molecular Formula C6H16N4O2 Melting Point N/A
MSDS USA Flash Point 117.2±27.9 °C

 Use of NOC-5


NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].

 Names

Name 3-[2-Hydroxy-1-(1-Methylethyl)-2-Nitrosohydrazino]-1-Propanamine Discontinued
Synonym More Synonyms

 NOC-5 Biological Activity

Description NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1].
Related Catalog
In Vitro NOC-5 (5-20 μM) in PBS led to a rapid increase in NO release on day one[1]. NOC-5 (100 μM, 24 h) activates only caspase-3; an increase in caspase-3 activity occurred after NO donor treatment: 1.62 (1.57-1.66) (P < 0.05). NOC-5 has pro-apoptotic action in Jurkat cells, but at the same time increased the level of anti-apoptotic proteins[2].
References

[1]. Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24.

[2]. Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38(7):799-802.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 270.1±42.0 °C at 760 mmHg
Molecular Formula C6H16N4O2
Molecular Weight 176.217
Flash Point 117.2±27.9 °C
Exact Mass 176.127319
PSA 90.60000
LogP 0.02
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.525

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26;S36
RIDADR NONH for all modes of transport

 Articles3

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J. Agric. Food Chem. 63 , 4815-26, (2015)

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Hrabie, J.A., et al.

J. Org. Chem. 58 , 1472, (1993)

 Synonyms

N-[3-aminopropyl(propan-2-yl)amino]-N-hydroxynitrous amide
3-(Aminopropyl)-1-hydroxy-3-isopropyl-2-oxo-1-triazene
1-(3-Aminopropyl)-2-hydroxy-1-isopropyl-3-oxotriazane
1-Propanamine, 3-[2-hydroxy-1-(1-methylethyl)-3-oxotriazanyl]-
3-(2-Hydroxy-1-(1-methylethyl)-2-nitrosohydrazino)-1-propanamine
MFCD00274389