thiomarinol
Modify Date: 2025-08-25 18:38:19
thiomarinol structure
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Common Name | thiomarinol | ||
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| CAS Number | 146697-04-3 | Molecular Weight | 640.80800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H44N2O9S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of thiomarinolThiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1]. |
| Name | thiomarinol A |
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| Synonym | More Synonyms |
| Description | Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1]. |
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| Related Catalog | |
| In Vitro | Thiomarinol A 显示抗菌活性，对 COL IleRS, LLMR COL IleRSV588F/V631F, LLMR COL IleRSF587V/V631F, LLMR COL IleRSV588F, IleRSV588F MupA, thiomarinol-resistant COL IleRSG593D, thiomarinol-resistant COL IleRSP606S 的 MIC 值分别为 0.002, 0.08, 0.04, 0.04, 0.50, 0.02, 0.01 µM[1]。 |
| References |
| Molecular Formula | C30H44N2O9S2 |
|---|---|
| Molecular Weight | 640.80800 |
| Exact Mass | 640.24900 |
| PSA | 238.64000 |
| LogP | 4.49400 |
| InChIKey | JIEMCPGFAXNCQW-UHFFFAOYSA-N |
| SMILES | CC(=CC(=O)OCCCCCCCC(=O)Nc1c2sscc-2[nH]c1=O)C(O)C1OCC(CC=CC(C)C(C)O)C(O)C1O |
| Thiomarinol |
| [8-oxo-8-[(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)amino]octyl] 4-[3,4-dihydroxy-5-(5-hydroxy-4-methylhex-2-enyl)oxan-2-yl]-4-hydroxy-3-methylbut-2-enoate |