146697-04-3

146697-04-3 structure

Name: thiomarinol
Chemical Name: thiomarinol A
CAS Number: 146697-04-3
Molecular Formula: C₃₀H₄₄N₂O₉S₂
Molecular Weight: 640.80800
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-07-11 16:45:11
Modify Date: 2024-02-29 15:17:48
Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1].

Name	thiomarinol A
Synonyms	Thiomarinol [8-oxo-8-[(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)amino]octyl] 4-[3,4-dihydroxy-5-(5-hydroxy-4-methylhex-2-enyl)oxan-2-yl]-4-hydroxy-3-methylbut-2-enoate

Description	Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Thiomarinol A 显示抗菌活性，对 COL IleRS, LLMR COL IleRSV588F/V631F, LLMR COL IleRSF587V/V631F, LLMR COL IleRSV588F, IleRSV588F MupA, thiomarinol-resistant COL IleRSG593D, thiomarinol-resistant COL IleRSP606S 的 MIC 值分别为 0.002, 0.08, 0.04, 0.04, 0.50, 0.02, 0.01 µM[1]。
References	[1]. Johnson RA, et al. Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. J Am Chem Soc. 2021 Aug 11;143(31):12003-12013.