thiomarinol

Names

[ Name ]:
thiomarinol

[Synonym ]:
Thiomarinol
[8-oxo-8-[(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)amino]octyl] 4-[3,4-dihydroxy-5-(5-hydroxy-4-methylhex-2-enyl)oxan-2-yl]-4-hydroxy-3-methylbut-2-enoate

Biological Activity

[Description]:

Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Thiomarinol A 显示抗菌活性，对 COL IleRS, LLMR COL IleRSV588F/V631F, LLMR COL IleRSF587V/V631F, LLMR COL IleRSV588F, IleRSV588F MupA, thiomarinol-resistant COL IleRSG593D, thiomarinol-resistant COL IleRSP606S 的 MIC 值分别为 0.002, 0.08, 0.04, 0.04, 0.50, 0.02, 0.01 µM[1]。

[References]

[1]. Johnson RA, et al. Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. J Am Chem Soc. 2021 Aug 11;143(31):12003-12013.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₄N₂O₉S₂

[ Molecular Weight ]:
640.80800

[ Exact Mass ]:
640.24900

[ PSA ]:
238.64000

[ LogP ]:
4.49400

Related Compounds

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